EPDM (Ethylene Propylene Diene Monomer) lining offers: (1) excellent resistance to seawater and chlorides, (2) temperature capability to 120°C continuous, (3) good abrasion resistance for sand-laden seawater, (4) lower cost. PTFE lining offers: (1) universal chemical resistance including acids and solvents, (2) temperature capability to 200°C, (3) zero absorption and minimal swelling, (4) but is softer and more susceptible to mechanical damage. For Saudi Arabian Red Sea seawater cooling (Jeddah, Yanbu), EPDM-lined valves are standard with 15-year service life. For chemical dosing lines where acid concentration varies, PTFE-lined valves are preferred despite higher cost.